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PHARMAFORGE
Infrastructure and expertise
for high-throughput experimentation
Gap Analysis
Gap Analysis
High-Throughput Experimentation
High-Throughput Experimentation
Chemical synthesis
Chemical synthesis
Open Access Labs
Direct-to-biology capabilities
Open Access Labs
Direct-to-biology capabilities
High-Throughput Screening
High-Throughput Screening
Biological validation
Biological validation
The PHARMAFORGE innovation platform brings together high-throughput experimentation (HTE) and high-throughput screening (HTS) in the cross-boarder region to accelerate drug discovery and development. By combining advanced automation, cutting-edge infrastructure, and multidisciplinary expertise, the platform enables rapid synthesis, testing, and validation of large libraries of compounds within a single streamlined workflow.
Through its Open Access Lab model, companies and research institutions can easily access specialized facilities, services, and expert support, lowering barriers to innovation. In parallel, a regional gap analysis identifies unmet needs in infrastructure, and experimental capabilities, ensuring the platform evolves in line with real market and scientific demands. This analysis actively engages stakeholders across the ecosystem to align technological development with user requirements and emerging opportunities.
The added value of integrating HTE and HTS within one platform lies in the seamless connection between chemical synthesis and biological validation, significantly shortening development cycles. Instead of operating in isolation, these complementary technologies interact in iterative loops, enabling faster identification and optimization of promising drug candidates.
We invite you to browse the available equipment below and contact us for futher steps.
Available Equipment
Available Equipment
High-Throughput Experimentation
High-Throughput Experimentation
Collaboration with the HighTru lab provides state-of-the-art and versatile reaction platforms for conventional, high-pressure, photocatalytic, and electrochemical reactions, both in a modular setup as well as via an integrated robotic system.
Included are capabilities for automated solid and liquid handling on small scale: miniaturised reactions on a 10 to 100 µmol scale, enabling reaction screening and compound characterisation, aided by semi-automated pipets and automated solid handling equipment.
Lastly, integrated high-throughput analysis and data processing allow for a fast sample preparation combined with a state-of-the-art UPLC–MS platform, using a software platform for high-throughput experimental design, sample analysis and data processing.
HTE Equipment Highlights: screening and library synthesis (≤ 250 μmol)
HTE Equipment Highlights: screening and library synthesis (≤ 250 μmol)
Liquid handling - Eppendorf single- and multi-channel, Formulatrix mantis, Formulatrix FLOi8 (coming soon), Opentrons Flex.
Solid handling - Mettler-Toledo semi-analytical balance, Chemspeed Crystal Powderdose.
Microplates - Paradox, V&P Scientific high-pressure 96-well plate (<20 bar) V&P tumble stirrer + heating blocks.
Sample preparation - Genevac EZ-2 (HCl), 96-well filtration manifold.
Glovebox - Jacomex.
Analysis & purification - Waters Acquity UPLC-DAD-MS-ELSD (SQD2), WASP HPLC-DAD-MS-ELSD (QDA II), Agilent GC-FID-MS , Biotage Selekt Magritek 90 MHz benchtop, access to Bruker 400, 500 and 700 MHz NMR.
Software - ACD/Labs Katalyst D2D (coming soon).
(Automated) synthesis platforms - Chemspeed FLEX iSynth, Biotage Initiator+ robot60
The HTE infrastructure is also complemented with Mechanochemistry capabilities, including ball milling and reactive extrusion, and Flow Chemistry capabilities, including reaction platforms such as Syrris ASIA and extraction using Zaiput MS10-5 multistage liquid-liquid extractor.
The HTE infrastructure is also complemented with Mechanochemistry capabilities, including ball milling and reactive extrusion, and Flow Chemistry capabilities, including reaction platforms such as Syrris ASIA and extraction using Zaiput MS10-5 multistage liquid-liquid extractor.
High-Throughput Screening
High-Throughput Screening
Collaboration with the highly flexible HTS platform of Princess Máxima Center enables the performance of a variety of high-throughput assays (e.g. ELISA, cell viability, staining), screens using different types of molecules (e.g. drugs, antibodies, or siRNAs) and read-out methods (e.g. absorbance-, luminescence- or fluorescence-based detection). The work is complemented with FACS and microscopy experimentation which can be performed at other core facilities of Princess Máxima Center.
HTS Equipment Highlights
The HTS facility is a state-of-the-art robotic system containing 20 different laboratory instruments, with the focus on facilitating research for pediatric cancer. As highlights, the facility has:
HTS Equipment Highlights
The HTS facility is a state-of-the-art robotic system containing 20 different laboratory instruments, with the focus on facilitating research for pediatric cancer. As highlights, the facility has:
Liquid handling - Beckman Coulter Biomek i7 Hybrid workstation.
Acoustic liquid handling - Echo 550 liquid handler for precise nL transfer volumes of drug solutions.
High content imaging system - Revvity Opera Phenix
Automated lab equipment - most common lab equipment is available in automated variant (e.g. centrifuge, sample heating/cooling)
Services and support
Services and support
Assay development and validation – support in the translation of research questions into assays suitable for high-throughput screening.
Carrying out the high-throughput screens
Data analysis support
Drug Libraries
Drug Libraries
Máxima Core Library - a drug library containing over 200 compounds specifically selected for pediatric oncology
Immuno-Oncology Library
Epigenetic Library
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